منابع مشابه
Activation of proto-oncogenes in human and mouse lung tumors.
Lung cancer is a leading cause of cancer-related deaths in several nations. Epidemiological studies have indicated that 85% of all lung cancer deaths and 30% of all cancer deaths in the U.S. are associated with tobacco smoking. Various chemicals in tobacco smoke are thought to react with DNA and to ultimately yield heritable mutations. In an effort to understand the molecular mechanisms involve...
متن کاملGTP-binding proteins as oncogenes in human tumors.
Ras oncogenes are the most commonly known oncogenes in human tumors; their prevalence in different types of tumors and their role in the development of these tumors have been discussed in recent reviews (1,2). We have investigated the biochemical mechanism that accounts for the activation of ras proto-oncogenes to become oncogenes. In normal cells, the ras p21 cycles between the active guanosin...
متن کاملDifferent expression patterns of oncogenes and proto-oncogenes in hereditary and carcinogen-induced tumors of Xiphophorus.
Hereditary melanoma in Xiphophorus hybrids carrying the melanoma-inducing Tu-Sd locus is caused by transcriptional activation of the Xmrk gene that resides at the Tu-Sd locus and encodes a novel member of receptor tyrosine kinases (RTK). In this study, a total of 27 hereditary melanomas from various hybrid genotypes harbouring 7 different Tu alleles were also found to over-express the correspon...
متن کاملOncogenes in Human Thyroid Cancers
Human thyroid epithelial (follicular) cells give rise to two malignant tumors—"follicular" carcinomas, which metastasize almost exclusively via the bloodstream, and "papillary" carcinomas, which metastasize predominantly via lymphatics (Williams, E. D. In: W. Duncan (ed.), Recent Results in Cancer Research: Thyroid Cancer, pp. 47-55. Berlin: Springer-Verlag, 1980). We have investigated whethe...
متن کاملNext-generation sequencing identified new oncogenes and tumor suppressor genes in human hepatic tumors
Genetic studies were performed in a French series of hepatocellular carcinomas. New oncogenes (NFE2L2) and tumor suppressor genes (IRF2, ARID1A and RPS6K3) were found to be recurrently altered. Moreover, a genotoxic signature was identified, raising the possible implication of a genotoxic exposure in the etiology of HCC, which remains to be characterized.
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ژورنال
عنوان ژورنال: Japanese Journal of Oral & Maxillofacial Surgery
سال: 1990
ISSN: 2186-1579,0021-5163
DOI: 10.5794/jjoms.36.2211